Event Title

Characterizing ASXL3

Location

Collier Library

Faculty Sponsor(s)

Dr. Cynthia Stenger

Event Website

https://www.una.edu/studentresearch/

Start Date

22-4-2019 1:00 PM

End Date

22-4-2019 2:00 PM

Document Type

Poster Presentation

Comments

In this study ASXL3 ser2214pro mutation was examined using virtual structural assessment and analysis of previous research in order to view the effects a mutation in the gene sequence of ASXL3 on the structure and function of the protein. The main structure generating software used was YASARA (Yet Another Scientific Artificial Reality Simulation). A model for the wild type ASXL3 and the mutated ASXL3 were generated using YASARA (Krieger, 2014). Models from I-Tasser and Uniprot were created and compared using the YASARA homology modeling tool. Various models were used to further examine the effects of the mutation on the structure. A molecular simulation was carried out to assess the changes a mutation would have in this domain, and gain corresponding data. The function of ASXL3 was examined using the Allen Brain Atlas and examination of mouse gene knockout studies. The comparison of these models shows that the mutation in ASXL3 affects the structural integrity of the protein (Fig. 1).

Included in

Biology Commons

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Apr 22nd, 1:00 PM Apr 22nd, 2:00 PM

Characterizing ASXL3

Collier Library

https://ir.una.edu/scholarsweek2019/2019/posters/14