Acute Coffee Ingestion With and Without Medium Chain Triglycerides Decreases Blood Oxidative Stress Markers and Increases Ketone Levels.

Document Type


Publication Date

Fall 11-5-2019


Background: Ingestion of ketone supplements, caffeine and medium chain triglycerides (MCTs) may all be effective strategies to increase blood levels of the ketone body beta-hydroxybutyrate (D-BHB). However, acute ingestion of a bolus of lipids may increase oxidative stress (OS). The purpose of the study was to investigate the impact of adding varying amounts of MCTs to coffee on blood levels of D-BHB and markers of OS. Methods: Ten college-aged men ingested coffee with 0g, 28g, and 42g of MCT in a randomized order. Blood samples were collected pre, as well as two and four hours postprandial and analyzed for D-BHB, total cholesterol (TC), high density lipoprotein cholesterol (HDL-c), glucose, triglycerides (TAG), insulin, as well as OS markers: advanced oxidation protein products (AOPP), glutathione (GSH), malondialdehyde (MDA), and hydrogen peroxide (H2O2). Results: All three treatments resulted in a significant increase in D-BHB, HDL-c, and TC, as well as a significant decrease in TAG, MDA, H2O2, and insulin. The 42g treatment was associated with significantly higher levels of AOPP and MDA. Conclusions: Acute ingestion of coffee results in favorable changes to markers of cardiometabolic health that were not impacted by the addition of 28g MCT. However, 42g MCT caused significantly greater OS.



Publication Title

Canadian Journal of Physiology and Pharmacology